Actovegin
Regulatory
Legal Status in 2026
No FDA approval for human use in the US; sold only as a research chemical.
This compound has no FDA approval for human use in the United States and is not available through licensed US pharmacies or compounding channels. It has not completed the clinical trials required for FDA approval. It may be sold online as a research chemical without quality controls, purity verification, or dosing standards. Always consult a physician.
About
About Actovegin
Actovegin is a deproteinized hemodialysate of calf blood containing low-molecular-weight peptides, nucleosides, amino acids, and oligosaccharides that improve cellular oxygen utilization and glucose uptake. It is approved and widely used in Europe, Russia, and Asia for ischemic conditions, diabetic neuropathy, wound healing, and stroke recovery. Athletes and biohackers use it off-label for enhanced recovery and cognitive performance.
Science
Mechanism of Action
Increases intracellular glucose transport and oxidative phosphorylation efficiency; activates pyruvate dehydrogenase to enhance aerobic energy metabolism; promotes angiogenesis and peripheral tissue oxygenation through multiple paracrine growth factor-like mechanisms.
Dosing
Typical Protocol
400–4,000 mg IV infusion daily for 10–20 days; 200 mg oral tablets used for maintenance in approved indications.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Evidence
Evidence Tier
Evidence from randomized controlled trials (RCTs) or large observational studies in humans. This is the gold standard: effects have been measured in controlled conditions and results are peer-reviewed and reproducible.
Availability
Provider availability
Actovegin has no FDA approval for human use and is not available through licensed US prescribing or compounding channels, so Vial does not list providers for it.
Compound comparisons
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This page evaluates compliance signals, not clinical outcomes. Consult a licensed physician before starting any therapy, medication, or treatment. Vial does not provide medical advice.