Actovegin
About
About Actovegin
Actovegin is a deproteinized hemodialysate of calf blood containing low-molecular-weight peptides, nucleosides, amino acids, and oligosaccharides that improve cellular oxygen utilization and glucose uptake. It is approved and widely used in Europe, Russia, and Asia for ischemic conditions, diabetic neuropathy, wound healing, and stroke recovery. Athletes and biohackers use it off-label for enhanced recovery and cognitive performance.
Science
Mechanism of Action
Increases intracellular glucose transport and oxidative phosphorylation efficiency; activates pyruvate dehydrogenase to enhance aerobic energy metabolism; promotes angiogenesis and peripheral tissue oxygenation through multiple paracrine growth factor-like mechanisms.
Dosing
Typical Protocol
400–4,000 mg IV infusion daily for 10–20 days; 200 mg oral tablets used for maintenance in approved indications.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound occupies a regulatory grey area in 2026. It is neither explicitly FDA-approved nor clearly illegal for personal use, but it lacks formal clinical approval and may not be legally sold for human use in all contexts. Proceed with caution: source quality is variable, and regulatory status can change. Always consult a physician.
Evidence
Evidence Tier
Evidence from randomized controlled trials (RCTs) or large observational studies in humans. This is the gold standard — effects have been measured in controlled conditions and results are peer-reviewed and reproducible.
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