Clomiphene
About
About Clomiphene
Clomiphene citrate is an FDA-approved selective estrogen receptor modulator (SERM) historically used for female infertility, now widely prescribed off-label in men to stimulate endogenous testosterone production while preserving fertility. Unlike exogenous testosterone, clomiphene maintains testicular function and spermatogenesis, making it the preferred choice for younger men seeking testosterone optimization who wish to remain fertile.
Science
Mechanism of Action
Blocks estrogen receptors in the hypothalamus and pituitary, preventing the negative feedback of estrogens on GnRH and LH/FSH secretion, thereby increasing pituitary output of gonadotropins that stimulate testicular testosterone production.
Dosing
Typical Protocol
12.5–50 mg oral daily or every other day; serum testosterone and LH monitored every 6–8 weeks.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound has completed clinical trials and received formal FDA approval for one or more indications. It can be legally prescribed by licensed physicians, filled at any licensed pharmacy, and may be covered by insurance. Off-label use by physicians is also legal. This is the highest level of regulatory clearance available in the US.
Evidence
Evidence Tier
Evidence from randomized controlled trials (RCTs) or large observational studies in humans. This is the gold standard — effects have been measured in controlled conditions and results are peer-reviewed and reproducible.
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