HGH
About
About HGH
Human growth hormone (somatropin) is a 191-amino acid protein produced by the pituitary gland that declines significantly with age. FDA-approved for GH deficiency, Turner syndrome, and other indications, it is used off-label in optimization medicine for body composition, recovery, and anti-aging applications. Direct HGH administration bypasses the natural pulsatile release pattern and requires careful dosing to avoid side effects. It is a Schedule III controlled substance precursor in some jurisdictions.
Science
Mechanism of Action
Binds GH receptors in the liver and peripheral tissues, stimulating IGF-1 synthesis and mediating anabolic, lipolytic, and protein-sparing effects; directly activates GH receptors in muscle, bone, and adipose tissue.
Dosing
Typical Protocol
0.5–2 IU subcutaneous injection daily or 5 days on / 2 days off; GH deficiency protocols range 0.2–1 IU/day.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound has completed clinical trials and received formal FDA approval for one or more indications. It can be legally prescribed by licensed physicians, filled at any licensed pharmacy, and may be covered by insurance. Off-label use by physicians is also legal. This is the highest level of regulatory clearance available in the US.
Evidence
Evidence Tier
Evidence from randomized controlled trials (RCTs) or large observational studies in humans. This is the gold standard — effects have been measured in controlled conditions and results are peer-reviewed and reproducible.
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