NADH
About
About NADH
NADH (nicotinamide adenine dinucleotide + hydrogen) is the reduced form of NAD+, functioning directly in cellular energy production and as an electron donor in the mitochondrial electron transport chain. Oral NADH supplements (as stabilized ENADA) have shown efficacy in clinical trials for chronic fatigue syndrome and Parkinson's disease, with effects on cognitive performance and energy. Unlike NAD+ precursors, NADH delivers the reduced coenzyme directly.
Science
Mechanism of Action
Donates electrons to complex I of the mitochondrial respiratory chain to generate the proton gradient driving ATP synthase; serves as a substrate for NQO1 enzyme to regenerate CoQ10; may directly increase dopamine synthesis by providing reducing equivalents for tyrosine hydroxylase.
Dosing
Typical Protocol
5–20 mg oral stabilized NADH (ENADA) on an empty stomach; IV form administered at 1–5 mg in clinical settings.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound has completed clinical trials and received formal FDA approval for one or more indications. It can be legally prescribed by licensed physicians, filled at any licensed pharmacy, and may be covered by insurance. Off-label use by physicians is also legal. This is the highest level of regulatory clearance available in the US.
Evidence
Evidence Tier
Evidence from randomized controlled trials (RCTs) or large observational studies in humans. This is the gold standard — effects have been measured in controlled conditions and results are peer-reviewed and reproducible.
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