NADH
Regulatory
Legal Status in 2026
No FDA-approved finished drug; permitted through 503A or 503B compounding with a prescription.
This compound is legal to prescribe and dispense through a licensed 503A or 503B compounding pharmacy with a valid prescription. It is not FDA-approved as a finished drug product, but compounding is explicitly permitted under federal law. Quality and sterility standards vary by pharmacy — look for PCAB-accredited compounders.
About
About NADH
NADH (nicotinamide adenine dinucleotide + hydrogen) is the reduced form of NAD+, functioning directly in cellular energy production and as an electron donor in the mitochondrial electron transport chain. Oral NADH supplements (as stabilized ENADA) have shown efficacy in clinical trials for chronic fatigue syndrome and Parkinson's disease, with effects on cognitive performance and energy. Unlike NAD+ precursors, NADH delivers the reduced coenzyme directly.
Science
Mechanism of Action
Donates electrons to complex I of the mitochondrial respiratory chain to generate the proton gradient driving ATP synthase; serves as a substrate for NQO1 enzyme to regenerate CoQ10; may directly increase dopamine synthesis by providing reducing equivalents for tyrosine hydroxylase.
Dosing
Typical Protocol
5–20 mg oral stabilized NADH (ENADA) on an empty stomach; IV form administered at 1–5 mg in clinical settings.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Evidence
Evidence Tier
Evidence from randomized controlled trials (RCTs) or large observational studies in humans. This is the gold standard — effects have been measured in controlled conditions and results are peer-reviewed and reproducible.
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This page evaluates compliance signals, not clinical outcomes. Consult a licensed physician before starting any therapy, medication, or treatment. Vial does not provide medical advice.