Rapamycin
About
About Rapamycin
Rapamycin (sirolimus) is an FDA-approved immunosuppressant that is the most robust longevity-extending drug identified in animal models, extending lifespan in mice by 9–14% even when started late in life. It works by inhibiting mTORC1, a central nutrient-sensing pathway. Low-dose, intermittent protocols are being studied and self-administered by longevity researchers for healthspan extension. It carries meaningful immunosuppression risks requiring physician oversight.
Science
Mechanism of Action
Inhibits mechanistic target of rapamycin complex 1 (mTORC1) by forming a complex with FKBP12, reducing protein synthesis, promoting autophagy, and mimicking caloric restriction signaling at the cellular level.
Dosing
Typical Protocol
1–6 mg oral once weekly (longevity protocol); immunosuppression doses are much higher. Requires CBC and metabolic monitoring.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound has completed clinical trials and received formal FDA approval for one or more indications. It can be legally prescribed by licensed physicians, filled at any licensed pharmacy, and may be covered by insurance. Off-label use by physicians is also legal. This is the highest level of regulatory clearance available in the US.
Evidence
Evidence Tier
Evidence from randomized controlled trials (RCTs) or large observational studies in humans. This is the gold standard — effects have been measured in controlled conditions and results are peer-reviewed and reproducible.
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