Resveratrol
About
About Resveratrol
Resveratrol is a polyphenol stilbene found in red wine and grape skins, intensively studied for longevity and metabolic benefits through sirtuin activation. While early animal data was compelling, human clinical results have been mixed, and concerns about bioavailability have driven interest in more potent analogs like pterostilbene. It remains widely used as a foundational longevity supplement despite equivocal human trial results.
Science
Mechanism of Action
Activates SIRT1 deacetylase to regulate PGC-1α (mitochondrial biogenesis), p53 (apoptosis), and NF-κB (inflammation); inhibits mTOR signaling; scavenges free radicals; and inhibits cyclooxygenase enzymes involved in inflammatory prostaglandin synthesis.
Dosing
Typical Protocol
150–500 mg oral daily; pterostilbene at 50–100 mg daily is considered a more bioavailable analog; best taken with food and piperine for absorption.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound has completed clinical trials and received formal FDA approval for one or more indications. It can be legally prescribed by licensed physicians, filled at any licensed pharmacy, and may be covered by insurance. Off-label use by physicians is also legal. This is the highest level of regulatory clearance available in the US.
Evidence
Evidence Tier
Evidence primarily from animal studies, cell cultures, or small pilot human trials. Results are promising but have not yet been confirmed in large-scale human RCTs. Effects in humans may differ from animal models.
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