Semax
About
About Semax
Semax is a synthetic heptapeptide derived from ACTH and developed in Russia, where it is approved and widely prescribed for cognitive decline, stroke recovery, and ADHD. It upregulates BDNF and NGF, making it one of the few compounds with strong neurotrophic evidence. Western use is primarily through compounding pharmacies and research chemical suppliers. It is intranasal and demonstrates rapid CNS penetration.
Science
Mechanism of Action
Stimulates production of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in the hippocampus and cortex; also modulates dopamine and serotonin systems to enhance working memory and attention.
Dosing
Typical Protocol
200–900 mcg intranasal spray once or twice daily for 14–28 day cycles; available as 0.1% or 1% solution.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound occupies a regulatory grey area in 2026. It is neither explicitly FDA-approved nor clearly illegal for personal use, but it lacks formal clinical approval and may not be legally sold for human use in all contexts. Proceed with caution: source quality is variable, and regulatory status can change. Always consult a physician.
Evidence
Evidence Tier
Evidence from randomized controlled trials (RCTs) or large observational studies in humans. This is the gold standard — effects have been measured in controlled conditions and results are peer-reviewed and reproducible.
Find a Verified Provider
See which Vial-verified providers offer Semax — with trust scores, legal credentials, and pricing transparency.