5-Amino-1MQ
About
About 5-Amino-1MQ
5-Amino-1MQ is a small molecule inhibitor of the enzyme NNMT (nicotinamide N-methyltransferase), which plays a central role in metabolic regulation and fat cell differentiation. By blocking NNMT it raises cellular NAD+ levels, activates SIRT1, and reduces adipogenesis — a novel mechanism for fat loss. Animal studies show significant reduction in body weight and adipose tissue mass. It is used in optimization medicine for metabolic health and fat loss.
Science
Mechanism of Action
Inhibits NNMT enzyme activity, preventing the methylation of nicotinamide and reducing S-adenosylhomocysteine levels; this increases NAD+ availability, activates sirtuins, and suppresses adipogenic gene expression in fat cells.
Dosing
Typical Protocol
50–200 mg oral once daily; limited human dosing data — protocols are extrapolated from animal studies.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound occupies a regulatory grey area in 2026. It is neither explicitly FDA-approved nor clearly illegal for personal use, but it lacks formal clinical approval and may not be legally sold for human use in all contexts. Proceed with caution: source quality is variable, and regulatory status can change. Always consult a physician.
Evidence
Evidence Tier
Evidence primarily from animal studies, cell cultures, or small pilot human trials. Results are promising but have not yet been confirmed in large-scale human RCTs. Effects in humans may differ from animal models.
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