5-Amino-1MQ
Regulatory
Legal Status in 2026
No FDA approval for human use in the US; sold only as a research chemical.
This compound has no FDA approval for human use in the United States and is not available through licensed US pharmacies or compounding channels. It has not completed the clinical trials required for FDA approval. It may be sold online as a research chemical without quality controls, purity verification, or dosing standards. Always consult a physician.
About
About 5-Amino-1MQ
5-Amino-1MQ is a small molecule inhibitor of the enzyme NNMT (nicotinamide N-methyltransferase), which plays a central role in metabolic regulation and fat cell differentiation. By blocking NNMT it raises cellular NAD+ levels, activates SIRT1, and reduces adipogenesis — a novel mechanism for fat loss. Animal studies show significant reduction in body weight and adipose tissue mass. It is used in optimization medicine for metabolic health and fat loss.
Science
Mechanism of Action
Inhibits NNMT enzyme activity, preventing the methylation of nicotinamide and reducing S-adenosylhomocysteine levels; this increases NAD+ availability, activates sirtuins, and suppresses adipogenic gene expression in fat cells.
Dosing
Typical Protocol
50–200 mg oral once daily; limited human dosing data — protocols are extrapolated from animal studies.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Evidence
Evidence Tier
Evidence primarily from animal studies, cell cultures, or small pilot human trials. Results are promising but have not yet been confirmed in large-scale human RCTs. Effects in humans may differ from animal models.
Availability
Provider availability
5-Amino-1MQ has no FDA approval for human use and is not available through licensed US prescribing or compounding channels, so Vial does not list providers for it.
This page evaluates compliance signals, not clinical outcomes. Consult a licensed physician before starting any therapy, medication, or treatment. Vial does not provide medical advice.