VIAL

TRT (Testosterone Replacement Therapy)

67 verified TRT providers in Vial’s directory.

What is TRT?

Testosterone replacement therapy has become one of the most prescribed treatments in optimization medicine, and one with the most variability in how it's delivered. The same protocol can look identical on two provider websites while differing significantly in physician involvement, pharmacy sourcing, and monitoring standards. Testosterone is a DEA Schedule III controlled substance with specific compliance requirements governing how it's prescribed and dispensed. Vial surfaces DEA registration status, pharmacy relationships, OIG exclusion history, and NPI credentials for every TRT provider in the directory.

Top TRT providers in Vial’s directory

Ranked by Trust Score. Showing 10 of 67. See all TRT providers →

How Vial evaluates TRT providers

Vial verifies TRT providers across six dimensions: regulatory standing, clinical transparency, pharmacy and fulfillment, commercial transparency, operating history, and industry standing. For TRT specifically, we surface providers with verified physician oversight, named pharmacy partners, and disclosed compound sourcing.

Read the full methodology →

TRT compounds

Compounds commonly used in TRT protocols. See all compounds →

HormoneFDA Approved
Testosterone Cypionate
A synthetic ester of testosterone, testosterone cypionate is an intramuscularly or subcutaneously administered androgen that provides sustained release of the hormone over approximately one to two weeks. It binds to androgen receptors throughout the body, promoting protein synthesis, muscle development, bone density maintenance, and secondary sex characteristics. The compound is primarily used in the treatment of male hypogonadism and as a component of gender-affirming hormone therapy.
FDA Approved→
HormoneClinical Trials
Testosterone Enanthate
Testosterone enanthate is a long-acting esterified form of testosterone with a half-life of 4–5 days, making weekly or twice-weekly injections standard. It is FDA-approved for hypogonadism and is one of the most prescribed TRT formulations in the US. In optimization medicine it is used to restore and maintain testosterone to youthful physiologic levels. It requires injection but offers stable serum levels with proper dosing frequency.
FDA Approved→
HormoneClinical Trials
HCG
Human chorionic gonadotropin (HCG) is an LH-mimicking hormone used in TRT to maintain testicular function, prevent atrophy, and preserve fertility during exogenous testosterone therapy. It is also used in male hypogonadism as a monotherapy to stimulate endogenous testosterone production. Compounded HCG remains available after FDA discontinued most branded injectable formulations. It is an essential component of fertility-preserving TRT protocols.
Legal Compounded→
HormoneFDA Approved
Anastrozole
Anastrozole is an FDA-approved aromatase inhibitor used in TRT protocols to manage estradiol levels that become elevated during testosterone therapy. By blocking aromatase enzyme activity, it prevents excess conversion of testosterone to estradiol, mitigating estrogenic side effects such as gynecomastia and water retention. It is one of the most commonly prescribed ancillary medications in men's health and hormone optimization.
FDA Approved→
HormoneClinical Trials
Clomiphene
Clomiphene citrate is an FDA-approved selective estrogen receptor modulator (SERM) historically used for female infertility, now widely prescribed off-label in men to stimulate endogenous testosterone production while preserving fertility. Unlike exogenous testosterone, clomiphene maintains testicular function and spermatogenesis, making it the preferred choice for younger men seeking testosterone optimization who wish to remain fertile.
FDA Approved→
HormoneClinical Trials
Enclomiphene
Enclomiphene is the trans-isomer of clomiphene citrate, isolated for its pure estrogen receptor antagonist activity without the estrogenic agonist effects of the cis-isomer (zuclomiphene). It produces cleaner testosterone stimulation with fewer estrogenic side effects compared to standard clomiphene. Though not yet FDA-approved as a standalone drug, it is available through compounding pharmacies and is preferred by many physicians for its improved tolerability profile.
Legal Compounded→
HormoneFDA Approved
Gonadorelin
Gonadorelin is a synthetic version of gonadotropin-releasing hormone (GnRH) used in optimization medicine to maintain pituitary-gonadal axis function during TRT, replacing HCG in protocols that require gonadal stimulation. When used as pulsatile injections, it mimics the natural hypothalamic GnRH pulse pattern to maintain LH/FSH secretion and testicular function. It is available through compounding pharmacies as a preferred alternative to HCG.
Legal Compounded→

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