Gonadorelin
About
About Gonadorelin
Gonadorelin is a synthetic version of gonadotropin-releasing hormone (GnRH) used in optimization medicine to maintain pituitary-gonadal axis function during TRT, replacing HCG in protocols that require gonadal stimulation. When used as pulsatile injections, it mimics the natural hypothalamic GnRH pulse pattern to maintain LH/FSH secretion and testicular function. It is available through compounding pharmacies as a preferred alternative to HCG.
Science
Mechanism of Action
Binds GnRH receptors on pituitary gonadotroph cells in a pulsatile fashion, stimulating release of LH and FSH, which in turn signal the testes to produce testosterone and maintain spermatogenesis — preserving the entire HPG axis during exogenous androgen use.
Dosing
Typical Protocol
100 mcg subcutaneous injection 2–3x per week, or 20–100 mcg via pulsatile pump every 60–120 minutes for fertility protocols.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound is legal to prescribe and dispense through a licensed 503A or 503B compounding pharmacy with a valid prescription. It is not FDA-approved as a finished drug product, but compounding is explicitly permitted under federal law. Quality and sterility standards vary by pharmacy — look for PCAB-accredited compounders.
Evidence
Evidence Tier
Supported by the clinical trial data required for FDA approval, representing the highest evidence bar. Safety and efficacy have been established in multiple phases of human clinical trials.
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