HormoneLegally CompoundedClinical Trials

HCG

About

About HCG

Human chorionic gonadotropin (HCG) is an LH-mimicking hormone used in TRT to maintain testicular function, prevent atrophy, and preserve fertility during exogenous testosterone therapy. It is also used in male hypogonadism as a monotherapy to stimulate endogenous testosterone production. Compounded HCG remains available after FDA discontinued most branded injectable formulations. It is an essential component of fertility-preserving TRT protocols.

Science

Mechanism of Action

Mimics luteinizing hormone (LH) by binding LH receptors on testicular Leydig cells, stimulating intratesticular testosterone production and maintaining spermatogenesis during exogenous androgen use.

Dosing

Typical Protocol

250–500 IU subcutaneous injection 2–3x per week alongside TRT; or 1,000–2,000 IU 3x weekly as monotherapy.

⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.

Regulatory

Legal Status in 2026

Legally Compounded

This compound is legal to prescribe and dispense through a licensed 503A or 503B compounding pharmacy with a valid prescription. It is not FDA-approved as a finished drug product, but compounding is explicitly permitted under federal law. Quality and sterility standards vary by pharmacy — look for PCAB-accredited compounders.

Evidence

Evidence Tier

Clinical Trials

Evidence from randomized controlled trials (RCTs) or large observational studies in humans. This is the gold standard — effects have been measured in controlled conditions and results are peer-reviewed and reproducible.