HCG
Also sold as Pregnyl, Novarel
Regulatory
Legal Status in 2026
Compounding restricted under the FDA 503A bulk-substance list.
Federal law restricts compounding of this compound. For compounds whose FDA-declared shortage has resolved, Section 503B bulk compounding rights have ended; Section 503A compounding remains possible only with a documented patient-specific clinical justification (a verified allergy to an inactive ingredient, or a strength the manufacturer does not make, not cost or convenience). For compounds affirmatively excluded by the FDA's Pharmacy Compounding Advisory Committee, compounding is not permitted under the bulk-substance list. The FDA-approved product (where one exists) is the appropriate default.
About
About HCG
Human chorionic gonadotropin (HCG) is an LH-mimicking hormone used in TRT to maintain testicular function, prevent atrophy, and preserve fertility during exogenous testosterone therapy. It is also used in male hypogonadism as a monotherapy to stimulate endogenous testosterone production. Compounded HCG remains available after FDA discontinued most branded injectable formulations. It is an essential component of fertility-preserving TRT protocols.
Science
Mechanism of Action
Mimics luteinizing hormone (LH) by binding LH receptors on testicular Leydig cells, stimulating intratesticular testosterone production and maintaining spermatogenesis during exogenous androgen use.
Dosing
Typical Protocol
250–500 IU subcutaneous injection 2–3x per week alongside TRT; or 1,000–2,000 IU 3x weekly as monotherapy.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Evidence
Evidence Tier
Evidence from randomized controlled trials (RCTs) or large observational studies in humans. This is the gold standard: effects have been measured in controlled conditions and results are peer-reviewed and reproducible.
Providers advertising HCG
A hCG mention is not a fulfillment check. FDA-approved hCG is sold as Pregnyl and Novarel. Before paying, ask which product is being dispensed and which pharmacy fills it.
Marek HealthMen's Health Telehealth · Peptide Therapy · LegitScript Certified
LifeForceMen's Health Telehealth · Peptide Therapy · LegitScript Certified
Olympia Pharmacy503A/503B Compounding Pharmacy · GLP-1 Specialist · PCAB & LegitScript
Hone HealthMen's Health Telehealth · GLP-1 Specialist · LegitScript Certified
Belmar PharmacyCompounding Pharmacy · TRT & HRT · PCAB Accredited
FagronCompounding Pharmacy
Defy MedicalMen's Health Telehealth · GLP-1 Specialist
Medical Health InstituteMen's Health Telehealth · Specialty Focused
AlphaMDMen's Health Telehealth · Peptide Therapy · LegitScript Certified
CenegenicsClinic & Medical Practice · TRT & HRT
Highland LongevityClinic & Medical Practice · GLP-1 Specialist
Talon WellnessTelehealth Platform
Compound comparisons
Compare HCG
HCG set against other compounds people weigh it against.
This page evaluates compliance signals, not clinical outcomes. Consult a licensed physician before starting any therapy, medication, or treatment. Vial does not provide medical advice.