HCG
Also sold as Pregnyl, Novarel
Regulatory
Legal Status in 2026
No FDA-approved finished drug; permitted through 503A or 503B compounding with a prescription.
This compound is legal to prescribe and dispense through a licensed 503A or 503B compounding pharmacy with a valid prescription. It is not FDA-approved as a finished drug product, but compounding is explicitly permitted under federal law. Quality and sterility standards vary by pharmacy — look for PCAB-accredited compounders.
About
About HCG
Human chorionic gonadotropin (HCG) is an LH-mimicking hormone used in TRT to maintain testicular function, prevent atrophy, and preserve fertility during exogenous testosterone therapy. It is also used in male hypogonadism as a monotherapy to stimulate endogenous testosterone production. Compounded HCG remains available after FDA discontinued most branded injectable formulations. It is an essential component of fertility-preserving TRT protocols.
Science
Mechanism of Action
Mimics luteinizing hormone (LH) by binding LH receptors on testicular Leydig cells, stimulating intratesticular testosterone production and maintaining spermatogenesis during exogenous androgen use.
Dosing
Typical Protocol
250–500 IU subcutaneous injection 2–3x per week alongside TRT; or 1,000–2,000 IU 3x weekly as monotherapy.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Evidence
Evidence Tier
Evidence from randomized controlled trials (RCTs) or large observational studies in humans. This is the gold standard — effects have been measured in controlled conditions and results are peer-reviewed and reproducible.
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This page evaluates compliance signals, not clinical outcomes. Consult a licensed physician before starting any therapy, medication, or treatment. Vial does not provide medical advice.