DHEA
About
About DHEA
Dehydroepiandrosterone (DHEA) is the most abundant steroid hormone in the human body and serves as a precursor to both androgens and estrogens. Serum DHEA declines sharply with age, reaching 20% of peak levels by age 70. Supplementation is used to support hormone balance, energy, immune function, and bone density. It is available over the counter in the US as a supplement.
Science
Mechanism of Action
Converted peripherally to testosterone and estrogens via steroidogenic enzymes, DHEA replenishes the substrate pool for sex hormone synthesis; it also exerts direct effects through DHEA-specific receptors in the brain and immune system.
Dosing
Typical Protocol
25–100 mg oral once daily in the morning; higher doses may cause androgenic side effects in women.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound has completed clinical trials and received formal FDA approval for one or more indications. It can be legally prescribed by licensed physicians, filled at any licensed pharmacy, and may be covered by insurance. Off-label use by physicians is also legal. This is the highest level of regulatory clearance available in the US.
Evidence
Evidence Tier
Evidence from randomized controlled trials (RCTs) or large observational studies in humans. This is the gold standard — effects have been measured in controlled conditions and results are peer-reviewed and reproducible.
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