GHK-Cu
Regulatory
Legal Status in 2026
No FDA approval for human use in the US; sold only as a research chemical.
This compound has no FDA approval for human use in the United States and is not available through licensed US pharmacies or compounding channels. It has not completed the clinical trials required for FDA approval. It may be sold online as a research chemical without quality controls, purity verification, or dosing standards. Always consult a physician.
About
About GHK-Cu
A naturally occurring copper-binding tripeptide found in human plasma, GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) functions as a signaling molecule that modulates gene expression related to tissue remodeling, collagen synthesis, and wound healing. Research demonstrates its capacity to stimulate fibroblast activity, promote angiogenesis, and exhibit anti-inflammatory and antioxidant properties. Primary applications include dermatological research for wound repair and skin aging, with emerging investigation into its potential roles in tissue regeneration and fibrosis modulation.
Science
Mechanism of Action
GHK-Cu binds copper in a square-planar coordination geometry, enabling it to transport copper into cells and participate in copper-dependent enzyme activation (SOD, lysyl oxidase). It activates collagen synthesis through TGF-β and Smad signaling, stimulates VEGF-mediated angiogenesis, upregulates antioxidant defenses, modulates inflammatory cytokines (reducing IL-1β, TNF-α), and acts as a transcriptional regulator affecting thousands of genes involved in cellular maintenance and repair.
Dosing
Typical Protocol
Topical: 1–5% GHK-Cu cream or serum applied to skin daily. Subcutaneous injection: 0.5–2 mg daily or 3–5 times weekly. Some protocols cycle: 4–8 weeks on, 2–4 weeks off. Inhaled GHK-Cu (experimental): for lung tissue applications.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Evidence
Evidence Tier
Evidence based on anecdotal reports, case studies, or observational data without controlled trials. User-reported outcomes may reflect placebo effect or confounding variables. Treat claims with appropriate skepticism.
Providers advertising GHK-Cu
This list reflects what providers publish, not confirmed inventory.
Strive PharmacyCompounding Pharmacy · GLP-1 Specialist · PCAB Accredited
Belmar PharmacyCompounding Pharmacy · TRT & HRT · PCAB Accredited
EnhancedGrey Market Vendor · Grey Market
Peptide PartnersPeptide Vendor · GLP-1 Specialist · Grey Market
Oath ResearchPeptide Vendor · Grey Market
Peptide SciencesPeptide Vendor · Grey Market
This page evaluates compliance signals, not clinical outcomes. Consult a licensed physician before starting any therapy, medication, or treatment. Vial does not provide medical advice.