Glutathione IV
About
About Glutathione IV
Intravenous glutathione is the reduced form of the body's master antioxidant tripeptide (gamma-glutamylcysteinylglycine), administered directly to bypass limited oral bioavailability. It is used in longevity and functional medicine for detoxification support, neurological conditions (including Parkinson's), immune enhancement, and skin brightening. IV delivery produces immediate plasma level elevation compared to oral or liposomal forms.
Science
Mechanism of Action
Directly replenishes intracellular reduced glutathione pools for conjugation of toxic compounds in phase II liver detoxification; scavenges reactive oxygen species; regenerates vitamins C and E; and supports mitochondrial function and immune cell activity.
Dosing
Typical Protocol
600–2,400 mg IV push or slow IV infusion 1–3x per week; often combined with vitamin C, B-complex, and magnesium in drip protocols.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound is legal to prescribe and dispense through a licensed 503A or 503B compounding pharmacy with a valid prescription. It is not FDA-approved as a finished drug product, but compounding is explicitly permitted under federal law. Quality and sterility standards vary by pharmacy — look for PCAB-accredited compounders.
Evidence
Evidence Tier
Evidence primarily from animal studies, cell cultures, or small pilot human trials. Results are promising but have not yet been confirmed in large-scale human RCTs. Effects in humans may differ from animal models.
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