Kisspeptin
About
About Kisspeptin
Kisspeptin is an endogenous neuropeptide produced in the hypothalamus that acts as the master regulator of the reproductive axis by directly stimulating GnRH neurons. It is being studied for hypogonadism, sexual dysfunction, and fertility applications where upstream HPG axis stimulation is desired. In men, kisspeptin-10 injections produce significant LH and testosterone surges. It represents a more upstream intervention than HCG or gonadorelin.
Science
Mechanism of Action
Binds KISS1R (GPR54) receptors on hypothalamic GnRH neurons to trigger GnRH pulse release, initiating a cascade of LH and FSH secretion from the pituitary and downstream gonadal sex hormone production.
Dosing
Typical Protocol
0.3–10 nmol/kg subcutaneous injection; research doses in human studies. Not standardized for clinical use.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound occupies a regulatory grey area in 2026. It is neither explicitly FDA-approved nor clearly illegal for personal use, but it lacks formal clinical approval and may not be legally sold for human use in all contexts. Proceed with caution: source quality is variable, and regulatory status can change. Always consult a physician.
Evidence
Evidence Tier
Evidence primarily from animal studies, cell cultures, or small pilot human trials. Results are promising but have not yet been confirmed in large-scale human RCTs. Effects in humans may differ from animal models.
Find a Verified Provider
See which Vial-verified providers offer Kisspeptin — with trust scores, legal credentials, and pricing transparency.