Klotho
About
About Klotho
Klotho (alpha-Klotho) is an aging-suppressor protein primarily expressed in the kidney and choroid plexus. It circulates as a soluble form shed by ADAM10/17 proteases and declines sharply with age. Preclinical studies in mice show that klotho overexpression extends lifespan by 20–30%, while klotho deficiency produces an accelerated-aging phenotype including vascular calcification, muscle wasting, and cognitive decline. Klotho has no FDA approval for human use and is not available through US pharmacies. It has not completed the human clinical trials required for FDA approval. It may be sold online as a research reagent without quality controls or dosing standards.
Science
Mechanism of Action
Co-receptor for FGF23 signaling; modulates phosphate and vitamin D homeostasis via FGFR1. As a circulating hormone, klotho activates PI3K/Akt and inhibits Wnt/beta-catenin and TGF-beta pathways — mechanisms linked to reduced senescence, preserved stem cell function, and attenuated organ fibrosis. Also inhibits IGF-1/insulin signaling, mimicking aspects of caloric restriction. Independent effects on ion channel regulation (TRPV5, ROMK) and synaptic plasticity are under investigation.
Dosing
Typical Protocol
No established human dosing protocol. Research use only — no approved therapeutic form exists for human use. Consult a physician before considering any research-grade peptide or protein of this class.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound has no FDA approval for human use in the United States and is not available through licensed US pharmacies or compounding channels. It has not completed the clinical trials required for FDA approval. It may be sold online as a research chemical without quality controls, purity verification, or dosing standards. Always consult a physician.
Evidence
Evidence Tier
Evidence primarily from animal studies, cell cultures, or small pilot human trials. Results are promising but have not yet been confirmed in large-scale human RCTs. Effects in humans may differ from animal models.
No verified providers offering Klotho yet
We audit new providers every week. Leave your email and we’ll let you know as soon as a Vial-verified provider starts offering Klotho.
Free. We’ll only email when there’s a real match.
This page evaluates compliance signals, not clinical outcomes. Consult a licensed physician before starting any therapy, medication, or treatment. Vial does not provide medical advice.