LL-37
Regulatory
Legal Status in 2026
No FDA-approved finished drug; permitted through 503A or 503B compounding with a prescription.
This compound is legal to prescribe and dispense through a licensed 503A or 503B compounding pharmacy with a valid prescription. It is not FDA-approved as a finished drug product, but compounding is explicitly permitted under federal law. Quality and sterility standards vary by pharmacy — look for PCAB-accredited compounders.
About
About LL-37
LL-37 is the only member of the cathelicidin family of human antimicrobial peptides, with broad-spectrum activity against bacteria, viruses, and fungi. Beyond its antimicrobial role it is a potent immunomodulator and wound-healing agent with emerging anti-cancer properties. It is studied for chronic infections, biofilm disruption, and inflammatory conditions. Available as a compounded peptide.
Science
Mechanism of Action
Disrupts microbial cell membranes via electrostatic interactions, while also binding LPS to neutralize endotoxin; in host cells it activates toll-like receptors and chemokine receptors to coordinate immune responses.
Dosing
Typical Protocol
100 mcg subcutaneous injection once daily; intranasal and topical formulations used for localized applications.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Evidence
Evidence Tier
Evidence primarily from animal studies, cell cultures, or small pilot human trials. Results are promising but have not yet been confirmed in large-scale human RCTs. Effects in humans may differ from animal models.
No verified providers offering LL-37 yet
We audit new providers every week. Leave your email and we’ll let you know as soon as a Vial-verified provider starts offering LL-37.
Free. We’ll only email when there’s a real match.
This page evaluates compliance signals, not clinical outcomes. Consult a licensed physician before starting any therapy, medication, or treatment. Vial does not provide medical advice.