MK-677
Regulatory
Legal Status in 2026
No FDA approval for human use in the US; sold only as a research chemical.
This compound has no FDA approval for human use in the United States and is not available through licensed US pharmacies or compounding channels. It has not completed the clinical trials required for FDA approval. It may be sold online as a research chemical without quality controls, purity verification, or dosing standards. Always consult a physician.
About
About MK-677
MK-677 (ibutamoren) is an orally active, non-peptide ghrelin mimetic that elevates GH and IGF-1 levels for 24 hours with a single daily dose. It is uniquely convenient among GH secretagogues due to its oral bioavailability. Common uses include muscle mass preservation, sleep improvement, and anti-aging applications. It is classified as a research chemical and not FDA-approved.
Science
Mechanism of Action
Selectively binds and activates ghrelin receptors (GHSR-1a), stimulating pulsatile GH release and sustained IGF-1 elevation without affecting cortisol or prolactin at therapeutic doses.
Dosing
Typical Protocol
10–25 mg oral once daily before bed; water retention and increased appetite are common at higher doses.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Evidence
Evidence Tier
Evidence primarily from animal studies, cell cultures, or small pilot human trials. Results are promising but have not yet been confirmed in large-scale human RCTs. Effects in humans may differ from animal models.
Availability
Provider availability
MK-677 has no FDA approval for human use and is not available through licensed US prescribing or compounding channels, so Vial does not list providers for it.
This page evaluates compliance signals, not clinical outcomes. Consult a licensed physician before starting any therapy, medication, or treatment. Vial does not provide medical advice.