MK-677
About
About MK-677
MK-677 (ibutamoren) is an orally active, non-peptide ghrelin mimetic that elevates GH and IGF-1 levels for 24 hours with a single daily dose. It is uniquely convenient among GH secretagogues due to its oral bioavailability. Common uses include muscle mass preservation, sleep improvement, and anti-aging applications. It is classified as a research chemical and not FDA-approved.
Science
Mechanism of Action
Selectively binds and activates ghrelin receptors (GHSR-1a), stimulating pulsatile GH release and sustained IGF-1 elevation without affecting cortisol or prolactin at therapeutic doses.
Dosing
Typical Protocol
10–25 mg oral once daily before bed; water retention and increased appetite are common at higher doses.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound occupies a regulatory grey area in 2026. It is neither explicitly FDA-approved nor clearly illegal for personal use, but it lacks formal clinical approval and may not be legally sold for human use in all contexts. Proceed with caution: source quality is variable, and regulatory status can change. Always consult a physician.
Evidence
Evidence Tier
Evidence primarily from animal studies, cell cultures, or small pilot human trials. Results are promising but have not yet been confirmed in large-scale human RCTs. Effects in humans may differ from animal models.
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