NAD+ IV
About
About NAD+ IV
Intravenous NAD+ administration bypasses gut absorption limitations to directly elevate systemic NAD+ levels, producing rapid improvements in energy, clarity, and cellular function reported by patients within hours of infusion. It is widely used in longevity clinics, addiction medicine (for withdrawal management), and neurological rehabilitation. IV NAD+ produces a faster and more dramatic acute effect than oral precursors like NMN or NR, though its long-term superiority over oral forms remains debated.
Science
Mechanism of Action
Directly repletes NAD+ in circulation for cellular uptake; restored NAD+ serves as coenzyme for sirtuin deacylases, PARP DNA repair enzymes, and redox reactions throughout the electron transport chain, rapidly reversing energy deficit in NAD+-depleted tissues.
Dosing
Typical Protocol
250–1,000 mg IV infusion over 2–8 hours; administered 1–5 consecutive days for intensive protocols, monthly for maintenance.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound is legal to prescribe and dispense through a licensed 503A or 503B compounding pharmacy with a valid prescription. It is not FDA-approved as a finished drug product, but compounding is explicitly permitted under federal law. Quality and sterility standards vary by pharmacy — look for PCAB-accredited compounders.
Evidence
Evidence Tier
Evidence primarily from animal studies, cell cultures, or small pilot human trials. Results are promising but have not yet been confirmed in large-scale human RCTs. Effects in humans may differ from animal models.
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This page evaluates compliance signals, not clinical outcomes. Consult a licensed physician before starting any therapy, medication, or treatment. Vial does not provide medical advice.