NR
Regulatory
Legal Status in 2026
No FDA-approved finished drug; permitted through 503A or 503B compounding with a prescription.
This compound is legal to prescribe and dispense through a licensed 503A or 503B compounding pharmacy with a valid prescription. It is not FDA-approved as a finished drug product, but compounding is explicitly permitted under federal law. Quality and sterility standards vary by pharmacy — look for PCAB-accredited compounders.
About
About NR
Nicotinamide riboside (NR) is an NAD+ precursor and vitamin B3 analog commercially available as Tru Niagen and other supplements. It effectively raises blood NAD+ levels in humans with a well-established safety profile. Clinical trials demonstrate improved muscle function in older adults and metabolic benefits in specific populations. It is one of the most studied NAD+ precursors in human clinical research.
Science
Mechanism of Action
Phosphorylated to NMN and then to NAD+ by NRK enzymes in cells; raises NAD+ levels to support sirtuin-mediated gene expression regulation, PARP DNA repair activity, and mitochondrial energy production.
Dosing
Typical Protocol
250–500 mg oral once or twice daily; may be combined with pterostilbene for synergistic sirtuin activation.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Evidence
Evidence Tier
Evidence from randomized controlled trials (RCTs) or large observational studies in humans. This is the gold standard — effects have been measured in controlled conditions and results are peer-reviewed and reproducible.
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This page evaluates compliance signals, not clinical outcomes. Consult a licensed physician before starting any therapy, medication, or treatment. Vial does not provide medical advice.