Acarbose
About
About Acarbose
Acarbose is an alpha-glucosidase inhibitor FDA-approved for type 2 diabetes that blunts post-meal glucose spikes by slowing carbohydrate digestion. In the NIA Interventions Testing Program, acarbose extended median lifespan in male mice by 22% — one of the strongest longevity signals seen in that program. It is increasingly used by longevity physicians as a post-meal glucose management tool. Its GI side effects are dose-dependent and often manageable.
Science
Mechanism of Action
Competitively inhibits alpha-glucosidase enzymes in the small intestinal brush border, slowing digestion and absorption of complex carbohydrates and reducing postprandial glucose and insulin excursions.
Dosing
Typical Protocol
25–100 mg oral with the first bite of each meal, 3x daily; start at 25 mg to minimize GI side effects.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound has completed clinical trials and received formal FDA approval for one or more indications. It can be legally prescribed by licensed physicians, filled at any licensed pharmacy, and may be covered by insurance. Off-label use by physicians is also legal. This is the highest level of regulatory clearance available in the US.
Evidence
Evidence Tier
Evidence from randomized controlled trials (RCTs) or large observational studies in humans. This is the gold standard — effects have been measured in controlled conditions and results are peer-reviewed and reproducible.
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