AOD-9604
About
About AOD-9604
A modified fragment of human growth hormone consisting of amino acids 177-191, this synthetic peptide was designed to retain the lipolytic properties of GH while lacking its growth-promoting and IGF-1-elevating effects. It acts primarily by stimulating lipolysis and inhibiting lipogenesis in adipose tissue. The compound has been investigated in clinical trials for obesity and is also used in some formulations for osteoarthritis, though regulatory approval status varies by jurisdiction.
Science
Mechanism of Action
AOD-9604 binds to the beta-3 adrenergic receptor and activates downstream cAMP signaling, stimulating lipolysis (breakdown of stored triglycerides) in adipose tissue. Unlike full HGH, it does not activate the IGF-1 signaling axis and does not upregulate glucose counter-regulation, making its metabolic profile more specific to fat mobilization. It may also have modest anti-lipogenic effects, reducing new fat storage.
Dosing
Typical Protocol
250–300 mcg subcutaneously daily, ideally before breakfast on an empty stomach. Cycles typically 8–12 weeks. Sometimes combined with CJC-1295/Ipamorelin for a body recomposition protocol. Modest caloric restriction and resistance training enhance efficacy.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound occupies a regulatory grey area in 2026. It is neither explicitly FDA-approved nor clearly illegal for personal use, but it lacks formal clinical approval and may not be legally sold for human use in all contexts. Proceed with caution: source quality is variable, and regulatory status can change. Always consult a physician.
Evidence
Evidence Tier
Evidence primarily from animal studies, cell cultures, or small pilot human trials. Results are promising but have not yet been confirmed in large-scale human RCTs. Effects in humans may differ from animal models.
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