Ca-AKG
About
About Ca-AKG
Calcium alpha-ketoglutarate (Ca-AKG) is a calcium salt of alpha-ketoglutarate, a key TCA cycle intermediate and epigenetic cofactor, shown in a clinical trial to reduce biological age by 8 years on epigenetic clocks after 7 months of supplementation. It supports collagen synthesis, serves as an ammonia scavenger, and acts as a cofactor for TET enzymes and histone demethylases that regulate DNA methylation patterns of aging.
Science
Mechanism of Action
Serves as an obligate cofactor for alpha-ketoglutarate-dependent dioxygenases including TET1/2/3 (DNA demethylation) and histone demethylases (KDMs), restoring youthful epigenetic patterns; also fuels the TCA cycle and reduces toxic ammonia accumulation in tissues.
Dosing
Typical Protocol
1,000–3,000 mg oral daily, split into 2 doses; the clinical trial showing epigenetic age reversal used 1,000 mg twice daily.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound has completed clinical trials and received formal FDA approval for one or more indications. It can be legally prescribed by licensed physicians, filled at any licensed pharmacy, and may be covered by insurance. Off-label use by physicians is also legal. This is the highest level of regulatory clearance available in the US.
Evidence
Evidence Tier
Evidence from randomized controlled trials (RCTs) or large observational studies in humans. This is the gold standard — effects have been measured in controlled conditions and results are peer-reviewed and reproducible.
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