Enclomiphene
About
About Enclomiphene
Enclomiphene is the trans-isomer of clomiphene citrate, isolated for its pure estrogen receptor antagonist activity without the estrogenic agonist effects of the cis-isomer (zuclomiphene). It produces cleaner testosterone stimulation with fewer estrogenic side effects compared to standard clomiphene. Though not yet FDA-approved as a standalone drug, it is available through compounding pharmacies and is preferred by many physicians for its improved tolerability profile.
Science
Mechanism of Action
Selectively antagonizes estrogen receptors in the hypothalamus and pituitary without the partial agonism of zuclomiphene, producing sustained LH and FSH elevation and robust endogenous testosterone stimulation with minimal estrogenic side effects.
Dosing
Typical Protocol
12.5–25 mg oral daily; typically produces testosterone increases of 100–200% from baseline within 4–8 weeks.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound is legal to prescribe and dispense through a licensed 503A or 503B compounding pharmacy with a valid prescription. It is not FDA-approved as a finished drug product, but compounding is explicitly permitted under federal law. Quality and sterility standards vary by pharmacy — look for PCAB-accredited compounders.
Evidence
Evidence Tier
Evidence from randomized controlled trials (RCTs) or large observational studies in humans. This is the gold standard — effects have been measured in controlled conditions and results are peer-reviewed and reproducible.
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