Fisetin
About
About Fisetin
Fisetin is a naturally occurring flavonoid senolytic found in strawberries and other fruits, shown to extend lifespan in mice by 10% when administered late in life — one of the most robust longevity interventions in the ITP program. It has demonstrated senolytic activity in human adipose tissue ex vivo and is being studied in clinical trials for Alzheimer's disease and COVID-19 long-haul syndrome. It crosses the blood-brain barrier, giving it neuroprotective potential.
Science
Mechanism of Action
Selectively promotes apoptosis in senescent cells through inhibition of PI3K/AKT/mTOR and BCL-2/BCL-xL pro-survival pathways; activates sirtuins; inhibits neuroinflammatory signaling through NF-κB suppression; and acts as a potent antioxidant flavonoid.
Dosing
Typical Protocol
100–500 mg oral daily continuously, or 1,000–1,500 mg for 2 consecutive days monthly in intermittent senolytic protocols.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound has completed clinical trials and received formal FDA approval for one or more indications. It can be legally prescribed by licensed physicians, filled at any licensed pharmacy, and may be covered by insurance. Off-label use by physicians is also legal. This is the highest level of regulatory clearance available in the US.
Evidence
Evidence Tier
Evidence primarily from animal studies, cell cultures, or small pilot human trials. Results are promising but have not yet been confirmed in large-scale human RCTs. Effects in humans may differ from animal models.
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