GHRP-2
About
About GHRP-2
GHRP-2 is a synthetic hexapeptide ghrelin mimetic that produces strong GH secretion with moderate appetite stimulation — less than GHRP-6 but more than ipamorelin. It also increases cortisol and prolactin to a modest degree. It is used in optimization medicine for body composition improvement and recovery. Available as a compounded peptide.
Science
Mechanism of Action
Binds ghrelin receptors (GHSR-1a) to stimulate pituitary GH release; also activates hypothalamic neuropeptide Y pathways contributing to appetite increases and modest cortisol elevation.
Dosing
Typical Protocol
100–300 mcg subcutaneous injection 2–3x daily, ideally on an empty stomach.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound occupies a regulatory grey area in 2026. It is neither explicitly FDA-approved nor clearly illegal for personal use, but it lacks formal clinical approval and may not be legally sold for human use in all contexts. Proceed with caution: source quality is variable, and regulatory status can change. Always consult a physician.
Evidence
Evidence Tier
Evidence primarily from animal studies, cell cultures, or small pilot human trials. Results are promising but have not yet been confirmed in large-scale human RCTs. Effects in humans may differ from animal models.
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