GLP-2
About
About GLP-2
GLP-2 (glucagon-like peptide-2) is a 33-amino-acid peptide secreted by intestinal L-cells in response to nutrient intake. It is the primary intestinotrophic hormone, promoting mucosal growth, reducing intestinal permeability, and slowing gastric emptying. Native GLP-2 has a half-life of roughly 7 minutes due to rapid DPP-4 cleavage and is not clinically useful in its unmodified form. Note: teduglutide (Gattex) is an FDA-approved DPP-4-resistant GLP-2 analog for short bowel syndrome and is a separate entry in this directory. The native GLP-2 peptide has no FDA approval for human use and is not available through US pharmacies or compounding channels.
Science
Mechanism of Action
GLP-2 receptor (GLP2R) agonist, primarily expressed in intestinal subepithelial myofibroblasts, enteric neurons, and smooth muscle. Receptor activation triggers paracrine release of EGF, KGF, and IGF-1, which drive intestinal crypt cell proliferation and villus elongation. Simultaneously reduces barrier permeability by upregulating tight-junction proteins (claudin-3, occludin) and suppresses proinflammatory cytokines via NF-kB inhibition. Also reduces bone resorption via an indirect mechanism involving calcitonin.
Dosing
Typical Protocol
No established human dosing protocol for native GLP-2. Research use only — the unmodified peptide has no approved therapeutic form in the US. For the approved GLP-2 analog, see Teduglutide. Consult a physician before considering any research-grade peptide of this class.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound has no FDA approval for human use in the United States and is not available through licensed US pharmacies or compounding channels. It has not completed the clinical trials required for FDA approval. It may be sold online as a research chemical without quality controls, purity verification, or dosing standards. Always consult a physician.
Evidence
Evidence Tier
Evidence primarily from animal studies, cell cultures, or small pilot human trials. Results are promising but have not yet been confirmed in large-scale human RCTs. Effects in humans may differ from animal models.
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This page evaluates compliance signals, not clinical outcomes. Consult a licensed physician before starting any therapy, medication, or treatment. Vial does not provide medical advice.