Hexarelin
About
About Hexarelin
Hexarelin is one of the most potent growth hormone secretagogues developed, producing significantly higher GH peaks than ipamorelin or GHRP-2. However, it causes rapid receptor desensitization with continuous use, requiring cycling protocols. It also has cardioprotective properties independent of GH release. Available as a research/compounded peptide.
Science
Mechanism of Action
Binds GHSR-1a with very high affinity, producing maximal GH pulse amplification; independent cardioprotective effects are mediated through CD36 receptors in myocardial tissue.
Dosing
Typical Protocol
100–200 mcg subcutaneous injection 2x daily; cycle 4–6 weeks on with 4-week breaks to prevent desensitization.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound occupies a regulatory grey area in 2026. It is neither explicitly FDA-approved nor clearly illegal for personal use, but it lacks formal clinical approval and may not be legally sold for human use in all contexts. Proceed with caution: source quality is variable, and regulatory status can change. Always consult a physician.
Evidence
Evidence Tier
Evidence primarily from animal studies, cell cultures, or small pilot human trials. Results are promising but have not yet been confirmed in large-scale human RCTs. Effects in humans may differ from animal models.
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