Metformin
About
About Metformin
Metformin is the world's most prescribed diabetes drug and a leading candidate for the first FDA-approved longevity drug via the TAME (Targeting Aging with Metformin) trial. Epidemiological data consistently shows metformin users have lower rates of cancer, cardiovascular disease, and all-cause mortality compared to matched diabetic controls. It is widely used off-label by longevity-focused physicians. Side effects are minimal at low doses.
Science
Mechanism of Action
Inhibits mitochondrial complex I, reducing hepatic glucose production and activating AMPK — a master energy sensor that promotes cellular stress resistance, autophagy, and mimics the gene expression signature of caloric restriction.
Dosing
Typical Protocol
500 mg–1,500 mg oral daily with food; extended-release formulation reduces GI side effects. B12 monitoring recommended long-term.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound has completed clinical trials and received formal FDA approval for one or more indications. It can be legally prescribed by licensed physicians, filled at any licensed pharmacy, and may be covered by insurance. Off-label use by physicians is also legal. This is the highest level of regulatory clearance available in the US.
Evidence
Evidence Tier
Evidence from randomized controlled trials (RCTs) or large observational studies in humans. This is the gold standard — effects have been measured in controlled conditions and results are peer-reviewed and reproducible.
Find a Verified Provider
See which Vial-verified providers offer Metformin — with trust scores, legal credentials, and pricing transparency.