Quercetin
About
About Quercetin
Quercetin is a naturally occurring flavonoid found in many fruits and vegetables, used as a nutraceutical senolytic in combination with dasatinib (D+Q) in clinical longevity research. It also has anti-inflammatory, antiviral, and AMPK-activating properties relevant to metabolic health and immune function. As a senolytic it is notably less potent than dasatinib but contributes additive senescent cell clearance and is far safer for frequent use.
Science
Mechanism of Action
Inhibits PI3K/AKT and BCL-xL pro-survival pathways in senescent cells, complementing dasatinib's kinase inhibition; also activates AMPK, inhibits mTOR, and acts as a direct free radical scavenger with anti-inflammatory effects on NF-κB signaling.
Dosing
Typical Protocol
500–1,000 mg oral twice daily for 3 consecutive days every 2–4 weeks (D+Q protocol); 250–500 mg daily for general anti-inflammatory use.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound has completed clinical trials and received formal FDA approval for one or more indications. It can be legally prescribed by licensed physicians, filled at any licensed pharmacy, and may be covered by insurance. Off-label use by physicians is also legal. This is the highest level of regulatory clearance available in the US.
Evidence
Evidence Tier
Evidence from randomized controlled trials (RCTs) or large observational studies in humans. This is the gold standard — effects have been measured in controlled conditions and results are peer-reviewed and reproducible.
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