FOXO4-DRI vs Sermorelin
FOXO4-DRI and Sermorelin are both peptide compounds evaluated on Vial: FOXO4-DRI is ruo with preclinical evidence, and Sermorelin is legally compoundable with clinical-trial evidence.
Vial summary · compiled from public records
At a glance
Sermorelin
- Category
- Peptide
- FDA / legal status
- Legally Compoundable
- Route
- Subcutaneous
Side by side
| Field | FOXO4-DRI | Sermorelin |
|---|---|---|
| Category | Peptide | Peptide |
| Brand names | — | — |
| FDA / legal status | RUO | Legally Compoundable |
| Evidence tier | Preclinical | Clinical Trials |
| Administration route | — | Subcutaneous |
| Compounding access | RUO | Legally Compoundable |
| Providers on Vial | 0 listed | 27 listed |
| Typical price band | Varies by provider | $ to $$$ |
Verified providers offering each
Ranked by Vial Score, Vial’s 0 to 100 score built from federal and state public records. The score evaluates the provider, not the compound.
FOXO4-DRI0 top providers
No surfaceable providers currently list FOXO4-DRI on Vial.
See all 0 providers offering foxo4-dri →About each compound
About FOXO4-DRI
FOXO4-DRI (FOXO4-D-Retro-Inverso) is a synthetic stapled peptide senolytic developed by de Keizer et al. (Nature Medicine, 2017). It disrupts the FOXO4–p53 interaction that keeps senescent cells alive, triggering apoptosis selectively in senescent cells. In mice, systemic administration reversed doxorubicin-induced liver damage, restored hair density in naturally aged mice, and improved fitness metrics. It has no FDA approval for human use and has not entered human clinical trials. It may be sold online as a research chemical without quality controls, purity verification, or dosing standards.
About Sermorelin
A synthetic analog of growth hormone-releasing hormone (GHRH), this 29-amino acid peptide stimulates the pituitary gland to produce and secrete endogenous growth hormone through binding to GHRH receptors. It functions by mimicking the N-terminal bioactive portion of native GHRH, promoting pulsatile GH release while preserving the body's natural feedback mechanisms. Primary applications include diagnostic testing of pituitary function and therapeutic use in growth hormone deficiency.
Descriptions compiled from public FDA records and manufacturer labeling where available. Not medical advice.
This page evaluates compliance signals, not clinical outcomes. Consult a licensed physician before starting any therapy, medication, or treatment. Vial does not provide medical advice.
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