Sermorelin vs Tesamorelin
Egrifta
Sermorelin and tesamorelin (sold as Egrifta) are both growth-hormone-releasing hormone analogues that stimulate the pituitary to produce growth hormone; tesamorelin is FDA approved for HIV-associated lipodystrophy, while sermorelin is available as a compounded preparation.
Vial summary · compiled from public records
At a glance
Sermorelin
- Category
- Peptide
- FDA / legal status
- Legally Compoundable
- Route
- Subcutaneous
Tesamorelin
Sold as Egrifta
- Category
- Peptide
- FDA / legal status
- FDA Approved
- Route
- Subcutaneous
Side by side
| Field | Sermorelin | Tesamorelin |
|---|---|---|
| Category | Peptide | Peptide |
| Brand names | — | Egrifta |
| FDA / legal status | Legally Compoundable | FDA Approved |
| Evidence tier | Clinical Trials | Clinical Trials |
| Administration route | Subcutaneous | Subcutaneous |
| Compounding access | Legally Compoundable | FDA-approved product, dispensed by prescription |
| Providers on Vial | 27 listed | 3 listed |
| Typical price band | $$ to $$$ | $$ to $$$ |
Verified providers offering each
Ranked by Vial Score, Vial’s 0 to 100 score built from federal and state public records. The score evaluates the provider, not the compound.
About each compound
About Sermorelin
A synthetic analog of growth hormone-releasing hormone (GHRH), this 29-amino acid peptide stimulates the pituitary gland to produce and secrete endogenous growth hormone through binding to GHRH receptors. It functions by mimicking the N-terminal bioactive portion of native GHRH, promoting pulsatile GH release while preserving the body's natural feedback mechanisms. Primary applications include diagnostic testing of pituitary function and therapeutic use in growth hormone deficiency.
About Tesamorelin
Tesamorelin is an FDA-approved GHRH analog indicated for HIV-associated lipodystrophy and is used off-label in optimization medicine for visceral fat reduction and cognitive enhancement. Clinical data shows significant reductions in visceral adipose tissue and emerging evidence suggests neuroprotective benefits in older adults. It produces stronger and more sustained GH elevation than sermorelin. Compounded versions are available through licensed pharmacies.
Descriptions compiled from public FDA records and manufacturer labeling where available. Not medical advice.
This page evaluates compliance signals, not clinical outcomes. Consult a licensed physician before starting any therapy, medication, or treatment. Vial does not provide medical advice.
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