Ipamorelin
About
About Ipamorelin
A synthetic pentapeptide growth hormone secretagogue, ipamorelin selectively stimulates pituitary release of growth hormone by mimicking ghrelin and binding to the growth hormone secretagogue receptor (GHS-R). Unlike earlier secretagogues, it demonstrates high selectivity for GH release with minimal effect on cortisol, prolactin, or appetite-regulating hormones. Research applications have focused on its potential use in growth hormone deficiency, age-related muscle loss, and bone metabolism studies.
Science
Mechanism of Action
Ipamorelin binds to the GHSR-1a (ghrelin receptor) on anterior pituitary somatotrophs with high affinity and selectivity. Receptor activation increases intracellular calcium and stimulates GH secretion. Its selectivity for the GHSR-1a over other GPCR receptors explains its minimal effect on cortisol and prolactin compared to GHRP-2 and GHRP-6, which have broader receptor activity.
Dosing
Typical Protocol
100–300 mcg subcutaneously 1–3 times daily, typically before bed and sometimes pre-workout. Commonly combined with CJC-1295 without DAC (Modified GRF 1-29) at matching doses. Protocols run for 3–6 month cycles with periodic IGF-1 monitoring. Administered subcutaneously in the abdomen or thigh.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Regulatory
Legal Status in 2026
This compound is legal to prescribe and dispense through a licensed 503A or 503B compounding pharmacy with a valid prescription. It is not FDA-approved as a finished drug product, but compounding is explicitly permitted under federal law. Quality and sterility standards vary by pharmacy — look for PCAB-accredited compounders.
Evidence
Evidence Tier
Evidence from randomized controlled trials (RCTs) or large observational studies in humans. This is the gold standard — effects have been measured in controlled conditions and results are peer-reviewed and reproducible.
Compare verified providers offering Ipamorelin
All 20 audited providers, ranked by Vial Check by default. Click any column to sort.
Compound comparisons
Compare Ipamorelin
Ipamorelin set against other compounds people weigh it against.
This page evaluates compliance signals, not clinical outcomes. Consult a licensed physician before starting any therapy, medication, or treatment. Vial does not provide medical advice.