Ipamorelin
Regulatory
Legal Status in 2026
No FDA-approved finished drug; permitted through 503A or 503B compounding with a prescription.
This compound is legal to prescribe and dispense through a licensed 503A or 503B compounding pharmacy with a valid prescription. It is not FDA-approved as a finished drug product, but compounding is explicitly permitted under federal law. Quality and sterility standards vary by pharmacy — look for PCAB-accredited compounders.
About
About Ipamorelin
A synthetic pentapeptide growth hormone secretagogue, ipamorelin selectively stimulates pituitary release of growth hormone by mimicking ghrelin and binding to the growth hormone secretagogue receptor (GHS-R). Unlike earlier secretagogues, it demonstrates high selectivity for GH release with minimal effect on cortisol, prolactin, or appetite-regulating hormones. Research applications have focused on its potential use in growth hormone deficiency, age-related muscle loss, and bone metabolism studies.
Science
Mechanism of Action
Ipamorelin binds to the GHSR-1a (ghrelin receptor) on anterior pituitary somatotrophs with high affinity and selectivity. Receptor activation increases intracellular calcium and stimulates GH secretion. Its selectivity for the GHSR-1a over other GPCR receptors explains its minimal effect on cortisol and prolactin compared to GHRP-2 and GHRP-6, which have broader receptor activity.
Dosing
Typical Protocol
100–300 mcg subcutaneously 1–3 times daily, typically before bed and sometimes pre-workout. Commonly combined with CJC-1295 without DAC (Modified GRF 1-29) at matching doses. Protocols run for 3–6 month cycles with periodic IGF-1 monitoring. Administered subcutaneously in the abdomen or thigh.
⚠ Protocol information is for educational purposes only. Dosing must be determined by a licensed physician based on individual health status and goals.
Evidence
Evidence Tier
Evidence from randomized controlled trials (RCTs) or large observational studies in humans. This is the gold standard — effects have been measured in controlled conditions and results are peer-reviewed and reproducible.
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This page evaluates compliance signals, not clinical outcomes. Consult a licensed physician before starting any therapy, medication, or treatment. Vial does not provide medical advice.