HCG vs Progesterone
HCG and Progesterone are both hormone compounds evaluated on Vial: HCG is available as a compounded preparation with clinical-trial evidence, and Progesterone is FDA approved with clinical-trial evidence, offered by 14 and 10 verified providers respectively.
Vial summary · compiled from public records
At a glance
HCG
Sold as Pregnyl, Novarel
- Category
- Hormone
- FDA / legal status
- Compoundable
- Route
- Subcutaneous, intramuscular
Progesterone
Sold as Prometrium
- Category
- Hormone
- FDA / legal status
- FDA Approved
- Route
- Oral, vaginal
Side by side
| Field | HCG | Progesterone |
|---|---|---|
| Category | Hormone | Hormone |
| Brand names | Pregnyl, Novarel | Prometrium |
| FDA / legal status | Compoundable | FDA Approved |
| Evidence tier | Clinical Trials | Clinical Trials |
| Administration route | Subcutaneous, intramuscular | Oral, vaginal |
| Compounding access | Available through 503A and 503B compounding pharmacies | FDA-approved product, dispensed by prescription |
| Providers on Vial | 14 listed | 10 listed |
| Typical price band | $$ to $$$ | $$ |
Verified providers offering each
Ranked by Confidence Rating, Vial’s 0 to 100 score built from federal and state public records. The score evaluates the provider, not the compound.
About each compound
About HCG
Human chorionic gonadotropin (HCG) is an LH-mimicking hormone used in TRT to maintain testicular function, prevent atrophy, and preserve fertility during exogenous testosterone therapy. It is also used in male hypogonadism as a monotherapy to stimulate endogenous testosterone production. Compounded HCG remains available after FDA discontinued most branded injectable formulations. It is an essential component of fertility-preserving TRT protocols.
About Progesterone
Bioidentical progesterone is FDA-approved for use in women and is a key component of female hormone replacement therapy, balancing estrogen's proliferative effects on the uterus and breast. It also has calming, sleep-promoting, and neuroprotective properties via its neurosteroid metabolite allopregnanolone. In optimization medicine it is used in both women and some men for hormonal balance and sleep improvement. Oral micronized progesterone (Prometrium) is the gold standard.
Descriptions compiled from public FDA records and manufacturer labeling where available. Not medical advice.
This page evaluates compliance signals, not clinical outcomes. Consult a licensed physician before starting any therapy, medication, or treatment. Vial does not provide medical advice.
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